You are not logged in. | Log in
In Progress
Clinical

GSE29807

Purpose

Low Birth Weight (LBW) newborns (with weight less than 2500g) suffer a higher frequency and severity of microbial infection than normal birth weight (NBW) newborns. Morbidity and mortality of LBW infants due to infectious diseases are known to be high and it has been associated with compromised immune functions, however, the complete understanding of the cause is lacking. We, therefore, conducted a gene expression study to identify all the defective pathways and functions in the LBW newborns using DNA microarray. RNA were isolated from the umbilical cord blood of the NBW and LBW newborns and processed for chip hybridisation. Our results suggest down-regulation of genes participating in several canonical pathways vital in the defense response against microbes and perpetuation of immune responses. Pattern recognition receptors (PRRs) and Interferon signaling appear to be most significantly impacted pathways. The information generated from this study may help in depth understanding of the cause of higher frequency of infections in LBW and thus, in turn help devise better therapeutic interventions.

Hypothesis

--

Experimental Design

Total 12 subjects were included in the study. 4 NBW newborns umblical cord blood samples served as control and 8 LBW newborns umblical cord blood samples were treated as the experimental samples for the study.

Experimental Variables

--

Controls

--

Methods

--

Additional Information

--

Microarray
Affymetrix HG-U133_Plus_2
12 Samples Loaded: 12
Human (Homo sapiens)
Whole Blood , Neonatal
Sample Set Spreadsheet
Please log in in order to upload files.
Samples Preview
Sample ID !Sample Title !Sample_title tissue Group name
GSM738804 Umblical Cord Blood from NBW newborn [C1] Umblical Cord Blood from NBW newborn [C1] Umblical Cord Blood normal birth weight
GSM738805 Umblical Cord Blood from NBW newborn [C2] Umblical Cord Blood from NBW newborn [C2] Umblical Cord Blood normal birth weight
GSM738806 Umblical Cord Blood from NBW newborn [C3] Umblical Cord Blood from NBW newborn [C3] Umblical Cord Blood normal birth weight
GSM738807 Umblical Cord Blood from NBW newborn [C4] Umblical Cord Blood from NBW newborn [C4] Umblical Cord Blood normal birth weight
GSM738808 Umblical Cord Blood from LBW newborn [E1] Umblical Cord Blood from LBW newborn [E1] Umblical Cord Blood low birth weight
Please log in in order to upload files.
File
GSE29807 modified.csv
Sample Set Spreadsheet
Log2 Transformed
  •   |  View in GXB »
Clinical Datasource
Links

Samples Viewer / Editor

All fields are editable except the "Sample ID" column. To edit a cell, click within the cell. To edit a "date" cell, click on the calendar icon. To cancel an edit, press the ESC key.

Sample ID !Sample Title !Sample Title Tissue Group name
GSM738804
Umblical Cord Blood from NBW newborn [C1]
Umblical Cord Blood from NBW newborn [C1]
Umblical Cord Blood
normal birth weight
GSM738805
Umblical Cord Blood from NBW newborn [C2]
Umblical Cord Blood from NBW newborn [C2]
Umblical Cord Blood
normal birth weight
GSM738806
Umblical Cord Blood from NBW newborn [C3]
Umblical Cord Blood from NBW newborn [C3]
Umblical Cord Blood
normal birth weight
GSM738807
Umblical Cord Blood from NBW newborn [C4]
Umblical Cord Blood from NBW newborn [C4]
Umblical Cord Blood
normal birth weight
GSM738808
Umblical Cord Blood from LBW newborn [E1]
Umblical Cord Blood from LBW newborn [E1]
Umblical Cord Blood
low birth weight
GSM738809
Umblical Cord Blood from LBW newborn [E2]
Umblical Cord Blood from LBW newborn [E2]
Umblical Cord Blood
low birth weight
GSM738810
Umblical Cord Blood from LBW newborn [E3]
Umblical Cord Blood from LBW newborn [E3]
Umblical Cord Blood
low birth weight
GSM738811
Umblical Cord Blood from LBW newborn [E4]
Umblical Cord Blood from LBW newborn [E4]
Umblical Cord Blood
low birth weight
GSM738812
Umblical Cord Blood from LBW newborn [E5]
Umblical Cord Blood from LBW newborn [E5]
Umblical Cord Blood
low birth weight
GSM738813
Umblical Cord Blood from LBW newborn [E6]
Umblical Cord Blood from LBW newborn [E6]
Umblical Cord Blood
low birth weight
GSM738814
Umblical Cord Blood from LBW newborn [E7]
Umblical Cord Blood from LBW newborn [E7]
Umblical Cord Blood
low birth weight
GSM738815
Umblical Cord Blood from LBW newborn [E8]
Umblical Cord Blood from LBW newborn [E8]
Umblical Cord Blood
low birth weight

Group Sets View in Gene Expression Browser

Name  
All Samples Default  View
In order to make new Group Sets or change settings, please log in.

Module Analysis

Group Set  
All Samples
Your bug report has been sent!