You are not logged in. | Log in
In Progress
Clinical
GSE69686_family
Purpose

Neonates manifest a unique host response to sepsis even among other children. Preterm neonates may experience sepsis soon after birth or during often protracted birth hospitalizations as they attain physiologic maturity. We examined the transcriptome using genome-wide expression profiling on prospectively collected peripheral blood samples from infants evaluated for sepsis within 24 hours after clinical presentation. Simultaneous plasma samples were examined for alterations in inflammatory mediators. Group designation (sepsis or uninfected) was determined retrospectively based on clinical exam and laboratory results over the next 72 hours from the time of evaluation. Unsupervised analysis showed the major node of separation between groups was timing of sepsis episode relative to birth (early, <3 days or late, >3 days). Principal component analyses revealed significant differences between patients with early or late sepsis despite the presence of similar key immunologic pathway aberrations in both groups. Unique to neonates, the uninfected state and host response to sepsis is significantly affected by timing relative to birth. Future therapeutic approaches may need to be tailored to the timing of the infectious event based on post-natal age.

Hypothesis

--

Experimental Design

We used human microarrays to detail the molecular profile of the events that occur following sepsis in hospitalized neonatesPlease note that 'uninfected chorio' represents babies who were not infected but had chorioamnionitis exposure

Experimental Variables

--

Controls

--

Methods

--

Additional Information

--

Microarray
Affymetrix Affymetrix Human Transcriptome v2
150 Samples Loaded: 150
Human (Homo sapiens)
Neonatal , Whole Blood
Sepsis
Sample Set Spreadsheet
Please log in in order to upload files.
Samples Preview
Sample ID !Sample Title infection tissue treatment Age group
GSM1707353 9A clinical sepsis whole blood EARLY-clinical sepsis EARLY
GSM1707354 9B clinical sepsis whole blood EARLY-clinical sepsis EARLY
GSM1707355 9C clinical sepsis whole blood EARLY-clinical sepsis EARLY
GSM1707356 10A uninfected whole blood EARLY-uninfected EARLY
GSM1707357 10B uninfected whole blood EARLY-uninfected EARLY
Please log in in order to upload files.
File

Log2 Transformed
  •   |  View in GXB »
Clinical Datasource
Links

Samples Viewer / Editor

All fields are editable except the "Sample ID" column. To edit a cell, click within the cell. To edit a "date" cell, click on the calendar icon. To cancel an edit, press the ESC key.

Sample ID !Sample Title Infection Tissue Treatment Age group Age in days Group name
GSM1707353
9A
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707354
9B
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707355
9C
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707356
10A
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707357
10B
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707358
11A
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707359
11B
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707360
11C
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707361
12A
uninfected
whole blood
LATE-uninfected
LATE
>3 days
late uninfected
GSM1707362
12B
uninfected
whole blood
LATE-uninfected
LATE
>3 days
late uninfected
GSM1707363
16A
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707364
16B
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707365
18B
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707366
18C
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707367
19B
uninfected chorio
whole blood
EARLY-uninfected chorio
EARLY
<3 days
early uninfected chorio
GSM1707368
19C
uninfected chorio
whole blood
EARLY-uninfected chorio
EARLY
<3 days
early uninfected chorio
GSM1707369
20C
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707370
20C 2
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707371
21C
uninfected chorio
whole blood
EARLY-uninfected chorio
EARLY
<3 days
early uninfected chorio
GSM1707372
22C
Sepsis
whole blood
EARLY Sepsis
EARLY
<3 days
early sepsis
GSM1707373
23B
uninfected chorio
whole blood
EARLY-uninfected chorio
EARLY
<3 days
early uninfected chorio
GSM1707374
23C
uninfected chorio
whole blood
EARLY-uninfected chorio
EARLY
<3 days
early uninfected chorio
GSM1707375
24A
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707376
24B
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707377
26A
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707378
26B
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707379
26C
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707380
28C
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707381
29A
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707382
29B
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707383
29C
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707384
30A
uninfected
whole blood
LATE-uninfected
LATE
>3 days
late uninfected
GSM1707385
4A
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707386
4B
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707387
4C
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707388
7A
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707389
7B
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707390
7C
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707391
8A
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707392
8B
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707393
8C
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707394
32B
uninfected chorio
whole blood
EARLY-uninfected chorio
EARLY
<3 days
early uninfected chorio
GSM1707395
32C
uninfected chorio
whole blood
EARLY-uninfected chorio
EARLY
<3 days
early uninfected chorio
GSM1707396
33C
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707397
34C
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707398
35B
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707399
35C
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707400
36C
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707401
37C
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707402
38A
uninfected chorio
whole blood
EARLY-uninfected chorio
EARLY
<3 days
early uninfected chorio
GSM1707403
38B
uninfected chorio
whole blood
EARLY-uninfected chorio
EARLY
<3 days
early uninfected chorio
GSM1707404
38C
uninfected chorio
whole blood
EARLY-uninfected chorio
EARLY
<3 days
early uninfected chorio
GSM1707405
39B
uninfected chorio
whole blood
EARLY-uninfected chorio
EARLY
<3 days
early uninfected chorio
GSM1707406
39C
uninfected chorio
whole blood
EARLY-uninfected chorio
EARLY
<3 days
early uninfected chorio
GSM1707407
40B
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707408
40C
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707409
41B
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707410
41C
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707411
43A
uninfected chorio
whole blood
EARLY-uninfected chorio
EARLY
<3 days
early uninfected chorio
GSM1707412
43B
uninfected chorio
whole blood
EARLY-uninfected chorio
EARLY
<3 days
early uninfected chorio
GSM1707413
43C
uninfected chorio
whole blood
EARLY-uninfected chorio
EARLY
<3 days
early uninfected chorio
GSM1707414
44B
uninfected
whole blood
LATE-uninfected
LATE
>3 days
late uninfected
GSM1707415
44C
uninfected
whole blood
LATE-uninfected
LATE
>3 days
late uninfected
GSM1707416
45C
uninfected chorio
whole blood
EARLY-uninfected chorio
EARLY
<3 days
early uninfected chorio
GSM1707417
46C
clinical sepsis
whole blood
LATE-clinical sepsis
LATE
>3 days
late clinical sepsis
GSM1707418
48A
uninfected
whole blood
LATE-uninfected
LATE
>3 days
late uninfected
GSM1707419
48B
uninfected
whole blood
LATE-uninfected
LATE
>3 days
late uninfected
GSM1707420
49B
Sepsis
whole blood
LATE Sepsis
LATE
>3 days
late sepsis
GSM1707421
50C
uninfected chorio
whole blood
EARLY-uninfected chorio
EARLY
<3 days
early uninfected chorio
GSM1707422
51A
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707423
51B
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707424
51C
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707425
52C
clinical sepsis
whole blood
LATE-clinical sepsis
LATE
>3 days
late clinical sepsis
GSM1707426
54B
Sepsis
whole blood
LATE Sepsis
LATE
>3 days
late sepsis
GSM1707427
54C
Sepsis
whole blood
LATE Sepsis
LATE
>3 days
late sepsis
GSM1707428
55C
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707429
56C
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707430
79A
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707431
79C
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707432
82A
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707433
82B
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707434
82C
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707435
94A
uninfected
whole blood
LATE-uninfected
LATE
>3 days
late uninfected
GSM1707436
94C
uninfected
whole blood
LATE-uninfected
LATE
>3 days
late uninfected
GSM1707437
96B
uninfected
whole blood
LATE-uninfected
LATE
>3 days
late uninfected
GSM1707438
99B
uninfected
whole blood
LATE-uninfected
LATE
>3 days
late uninfected
GSM1707439
99C
uninfected
whole blood
LATE-uninfected
LATE
>3 days
late uninfected
GSM1707440
100A
uninfected chorio
whole blood
EARLY-uninfected chorio
EARLY
<3 days
early uninfected chorio
GSM1707441
100B
uninfected chorio
whole blood
EARLY-uninfected chorio
EARLY
<3 days
early uninfected chorio
GSM1707442
103A
Sepsis
whole blood
LATE Sepsis
LATE
>3 days
late sepsis
GSM1707443
103B
Sepsis
whole blood
LATE Sepsis
LATE
>3 days
late sepsis
GSM1707444
104A
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707445
104B
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707446
105A
uninfected
whole blood
LATE-uninfected
LATE
>3 days
late uninfected
GSM1707447
105B
uninfected
whole blood
LATE-uninfected
LATE
>3 days
late uninfected
GSM1707448
109B
clinical sepsis
whole blood
LATE-clinical sepsis
LATE
>3 days
late clinical sepsis
GSM1707449
109C
clinical sepsis
whole blood
LATE-clinical sepsis
LATE
>3 days
late clinical sepsis
GSM1707450
112A
Sepsis
whole blood
EARLY Sepsis
EARLY
<3 days
early sepsis
GSM1707451
112C
Sepsis
whole blood
EARLY Sepsis
EARLY
<3 days
early sepsis
GSM1707452
115C
Sepsis
whole blood
LATE Sepsis
EARLY
<3 days
late sepsis
GSM1707453
116B
Sepsis
whole blood
LATE Sepsis
EARLY
<3 days
late sepsis
GSM1707454
116C
Sepsis
whole blood
LATE Sepsis
EARLY
<3 days
late sepsis
GSM1707455
111C
Sepsis
whole blood
LATE Sepsis
EARLY
<3 days
late sepsis
GSM1707456
118C
Sepsis
whole blood
EARLY Sepsis
EARLY
<3 days
early sepsis
GSM1707457
110C
uninfected chorio
whole blood
EARLY-uninfected chorio
EARLY
<3 days
early uninfected chorio
GSM1707458
119B
uninfected
whole blood
LATE-uninfected
LATE
>3 days
late uninfected
GSM1707459
121C
Sepsis
whole blood
LATE Sepsis
LATE
>3 days
late sepsis
GSM1707460
125A
Sepsis
whole blood
LATE Sepsis
LATE
>3 days
late sepsis
GSM1707461
125C
Sepsis
whole blood
LATE Sepsis
LATE
>3 days
late sepsis
GSM1707462
301A
uninfected
whole blood
LATE-uninfected
LATE
>3 days
late uninfected
GSM1707463
301B
uninfected
whole blood
LATE-uninfected
LATE
>3 days
late uninfected
GSM1707464
301C
uninfected
whole blood
LATE-uninfected
LATE
>3 days
late uninfected
GSM1707465
111B
Sepsis
whole blood
LATE Sepsis
EARLY
<3 days
late sepsis
GSM1707466
58C
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707467
59A
uninfected chorio
whole blood
EARLY-uninfected chorio
EARLY
<3 days
early uninfected chorio
GSM1707468
59B
uninfected chorio
whole blood
EARLY-uninfected chorio
EARLY
<3 days
early uninfected chorio
GSM1707469
60A
uninfected chorio
whole blood
EARLY-uninfected chorio
EARLY
<3 days
early uninfected chorio
GSM1707470
60B
uninfected chorio
whole blood
EARLY-uninfected chorio
EARLY
<3 days
early uninfected chorio
GSM1707471
61B
uninfected chorio
whole blood
EARLY-uninfected chorio
EARLY
<3 days
early uninfected chorio
GSM1707472
64A
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707473
64B
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707474
65A
uninfected chorio
whole blood
EARLY-uninfected chorio
EARLY
<3 days
early uninfected chorio
GSM1707475
67B
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707476
68A
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707477
68B
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707478
69A
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707479
70A
uninfected
whole blood
LATE-uninfected
LATE
>3 days
late uninfected
GSM1707480
71A
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707481
302A
Sepsis
whole blood
LATE Sepsis
LATE
>3 days
late sepsis
GSM1707482
302B
Sepsis
whole blood
LATE Sepsis
LATE
>3 days
late sepsis
GSM1707483
302C
Sepsis
whole blood
LATE Sepsis
LATE
>3 days
late sepsis
GSM1707484
113C
Sepsis
whole blood
EARLY Sepsis
EARLY
<3 days
early sepsis
GSM1707485
306A
uninfected
whole blood
LATE-uninfected
LATE
>3 days
late uninfected
GSM1707486
306B
uninfected
whole blood
LATE-uninfected
LATE
>3 days
late uninfected
GSM1707487
306C
uninfected
whole blood
LATE-uninfected
LATE
>3 days
late uninfected
GSM1707488
110Cr2
uninfected chorio
whole blood
EARLY-uninfected chorio
EARLY
<3 days
early uninfected chorio
GSM1707489
92A
clinical sepsis
whole blood
EARLY-clinical sepsis
EARLY
<3 days
early clinical sepsis
GSM1707490
133A
Sepsis
whole blood
EARLY Sepsis
EARLY
<3 days
early sepsis
GSM1707491
133B
Sepsis
whole blood
EARLY Sepsis
EARLY
<3 days
early sepsis
GSM1707492
137C
clinical sepsis
whole blood
LATE-clinical sepsis
LATE
>3 days
late clinical sepsis
GSM1707493
311B
clinical sepsis
whole blood
LATE-clinical sepsis
LATE
>3 days
late clinical sepsis
GSM1707494
135B
Sepsis
whole blood
EARLY Sepsis
EARLY
<3 days
early sepsis
GSM1707495
135C
Sepsis
whole blood
EARLY Sepsis
EARLY
<3 days
early sepsis
GSM1707496
83A
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707497
84B
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707498
84A
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707499
53B
uninfected
whole blood
EARLY-uninfected
EARLY
<3 days
early uninfected
GSM1707500
57A
uninfected
whole blood
LATE-uninfected
LATE
>3 days
late uninfected
GSM1707501
57B
uninfected
whole blood
LATE-uninfected
LATE
>3 days
late uninfected
GSM1707502
57C
uninfected
whole blood
LATE-uninfected
LATE
>3 days
late uninfected

Group Sets View in Gene Expression Browser

Name  
All Samples Default  View
In order to make new Group Sets or change settings, please log in.

Module Analysis

Group Set  
All Samples
Your bug report has been sent!